TaperMate

Zopiclone liquid taper calculator

Dissolving a zopiclone tablet in water or full-fat milk lets you measure small doses with an oral syringe. Enter your numbers below to see how much of the liquid to take — and the formula so you can check it yourself.

Zopiclone · liquid

Single dose calculator

mg
Strength of the tablet you're using.
mL
How much water or full-fat milk* you disperse the tablet in. *Benzodiazepines and Z-drugs are more soluble in fat than in water, so full-fat milk can be used instead of water. Source: Maudsley Deprescribing Guidelines.
mg
What you want to take today.
mL
Calculated for you.
Take this much of the liquid
5mL
from the 10 mL you mixed, to get a 3.75 mg dose.
Formula volume to take = (target dose ÷ tablet strength) × liquid volume
With your numbers (3.75 mg ÷ 7.5 mg) × 10 mL = 5 mL
Measure to the nearest 0.1 mL on your syringe.
Measure to nearest 0.1 mL
Standard oral syringes read to 0.1 mL. For very small volumes, ask your pharmacist about a 1 mL syringe.
Item 14L · Verify Validate this calculation
Tablet strength
7.5 mg per tablet (or part-tablet)
Liquid volume
10 mL
Target dose
3.75 mg — what you want to take
Volume to take
5 mL — from the 10 mL liquid
Check
7.5 × (5 ÷ 10) = 3.75 mg ✓
Every input and the formula are shown so you can verify the result by hand.
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The liquid method, step by step

Method The maths above gives the number; these steps are the practical part. Adapted from the RELEASE Toolkit. Adjust the amounts to what your prescriber agreed.
  1. Cut a zopiclone tablet to the portion you need with a pill cutter.
  2. Crush the piece between two spoons over a small plate.
  3. Stir it into a measured volume of water or full-fat milk* to make a known concentration. Shake or stir to disperse.
  4. Stir again immediately before drawing your dose — the active ingredient settles quickly.
  5. Measure your prescribed dose with an oral syringe and take it.
  6. Make a fresh liquid each day, keep it in the fridge, and discard any unused liquid in the rubbish at the end of the day.

*Benzodiazepines and Z-drugs are more soluble in fat than in water, so full-fat milk can be used instead of water. Source: Maudsley Deprescribing Guidelines.

About the liquid method

You crush or disperse a known strength of tablet into a known volume of water or full-fat milk, then draw the fraction containing your target dose. Works for many SSRIs and some other psychotropics — not for modified-release formulations.

The dedicated sertraline · liquid page has a step-by-step worked example adapted from the RELEASE Toolkit; the same method applies to most immediate-release SSRI tablets.

Next step

Plan your full taper in TaperMate

This calculator handles one dose. The TaperMate app calculates a full reduction schedule with hold periods, microtapering and symptom monitoring — so each new dose is one tap away, not a daily maths problem.

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Sources to discuss with your prescriber